A graduate of the University of Oregon in 1998 with a bachelor's degree in sociology and a minor in business administration, Griffin played four seasons of football with the Ducks earning All-Pacific-10 Conference honors as a wide receiver in 1996 and 1998. He is fifth on Oregon's single season list for receptions with 58, and sixth on the single season list for receiving yards with 1,038. Griffin has the Oregon record for the most 100-yard receiving games in a season at five.
He played in three postseason bowl games for the Ducks including the 1998 Aloha Bowl, the 1995 Cotton Bowl and the 1994 Rose Bowl.
Following his collegiate career, Griffin spent four seasons in the NFL. He was originally signed as a free agent by the San Francisco 49ers, before playing two seasons (1999 and 2000) with the Cincinnati Bengals. He was also a member of the 2001 St. Louis Rams which won the NFC Championship.